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Events
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Welcome
Watch this brief welcome message from David Meeker, MD, Chairman, President, and CEO of Rhythm Pharmaceuticals, Inc.
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Rare MCR4 Pathway Diseases
Unlike general obesity, rare genetic diseases of obesity are caused by an impactful variant in a gene, resulting in the dysfunction of key systems that regulate energy balance.1 The melanocortin-4 receptor (MC4R) pathway is one such key system.1,2 This dysfunction can lead to hyperphagia (also known as pathological, insatiable hunger) and early-onset, severe obesity, the hallmark symptoms of rare genetic diseases of obesity.1,3
Featured Research
Learn about Rhythm's latest publications and conference presentations, including a poster describing the study design of the phase 2 DAYBREAK trial, which will evaluate setmelanotide for weight loss and hunger reduction in patients with a genetic variant associated with the melanocortin-4 receptor (MC4R) pathway.
Resources
Continue expanding your understanding of these disease states with the latest resources available from Rhythm Pharmaceuticals related to rare genetic diseases of obesity.
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References
- Huvenne H, et al. Obes Facts. 2016;9(3):158-173.
- da Fonseca ACP, et al. J Diabetes Complications. 2017;31(10):1549-1561.
- Heymsfield SB, et al. Obesity (Silver Spring). 2014;22(suppl 1):S1-S17.